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Like other GLP-1 receptor agonists, Orforglipron works by mimicking a hormone that targets areas of the brain involved in appetite regulation and blood sugar control

If taste disturbances co-occur with severe nausea, contacting your prescriber ensures you're not experiencing a more serious reaction

Jaundice: Yellowing of your skin or the whites of your eyes

Impact of Pomegranate Juice on the Pharmacokinetics of CYP3A4- and CYP2C9-Mediated Drugs Metabolism: A Preclinical and Clinical Review

This decision followed a comprehensive FDA review that found no increased risk of suicidal thoughts or behaviors associated with GLP-1 use

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