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Experimental Eye Research, 83 (6), 1366-1372

The compound's mechanism of action through circadian rhythm pathways makes timing particularly relevant

Under-eye skin is very thin, which is why the filler can create discolouration on the skin

This generally clears up pretty quickly but can last up to a week for some patients

The increased cost and additional injection requirement mean the combination approach represents a step up in commitment

Get started In clinical trials of the oral Wegovy (semaglutide) pill, participants taking the medication with diet and exercise achieved average weight loss of about 14%17% over ~64 weeks compared with ~2% with placebo