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This added pathway is why many clinicians are beginning to view it as the next phase of metabolic therapy, especially for patients who have plateaued

Acute exercise temporarily increases DPP-4 activity (likely evolutionary adaptation to manage incretin hormones during physical stress), but chronic regular exercise appears to reduce baseline DPP-4 expression

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Distribution studies indicate PT-141 crosses the blood-brain barrier effectively, consistent with its centrally-mediated mechanism of action