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This specialist assessment may include additional imaging, consideration of liver biopsy, and screening for complications such as esophageal varices

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The combination of abrine and anti-PD-1 antibody treatment synergistically repressed the tumor growth in HCC by inducing CD4 + or CD8 + T cells, decreasing Foxp3 + Treg cells, and inhibiting immune-suppressive molecules such as IDO1, CD47, and PD-L1(Liang et al., 2023b)

However, long-term safety data including cardiovascular outcomes, heart-rate effects, and optimal dosing are still being gathered in Phase 3 studies, and no definitive safety conclusions can be drawn at this stage