Its prevalence is increasing worldwide, and, like obesity, it affects progressively younger populations compared to the past, with potentially greater impact on chronic complications
If you've been consistent with daily dosing, proper reconstitution, and refrigerated storage, and still see zero change at 16 weeks, the issue is likely absorption or individual receptor sensitivity rather than insufficient dose
This approach uses higher daily doses during the first 4 weeks before tapering to maintenance
They are also beneficial for individuals with poor dietary intake of B12 (including vegetarians and vegans), older adults with reduced absorption, patients with digestive conditions like Crohns disease or celiac disease, and those managing conditions like anemia, sciatica, or peripheral neuropathy
Staggering doses throughout the day can accommodate both protocols
on the root surface, rinsed with sterile saline, then EMD was applied onto the clean and dry root surface and the suture was than tightened and secured the knot
