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Without careful dietary support, you may lose lean muscle mass, not just fat

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Small Molecule Amylin Mimetics: Companies are developing oral formulations of amylin analogues

Bariatric surgery--which seeks to reduce the size of the stomach or bypass part of the GI tract--was conceived in the 1960s when surgeons observed that gastric cancer patients who had part of the stomach removed (subtotal gastrectomy) went on to lose weight

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These are the glucose-dependent insulinotropic polypeptide (GIP), GLP-1, and glucagon, which regulate blood sugar, appetite, and metabolism.