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PKA activation phosphorylates MITF, driving transcriptional upregulation of tyrosinase, TRP-1, and TRP-2key enzymes in the eumelanin synthesis pathway

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Subgroup analyses were not reweighted between the subgroup of semaglutide and DPP4i users, and only bivariate analyses were conducted in subgroup analyses

that folate supplementation can also reduce the incidence of depression, especially in women (81)

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The mechanistic basis involves GHK-CuCuSOD1 (cytoplasmic Cu/Zn-SOD) enhanced activity (NBT reduction assay: +31 5%), reducing HO-driven JNK activation via ASK1-Thr845 phosphorylation (ThioredoxinReductase-Trx1 redox buffer maintained)