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Retatrutide is contraindicated during pregnancy and breastfeeding

Routine labs (CBC, CMP including ALT/AST, lipid panel, fasting glucose, HbA1c) before starting and on a regular schedule under clinician oversight

Be mindful of other medications Inform your doctor about all medications and supplements you're taking to avoid potential interactions

The improvements in fasting food cravings and appetite score occurred in parallel to the reductions of five sub-scales of food craving (desire, anticipation of positive reinforcement, anticipation of negative reinforcement, lack of control, and hunger scores), and while cognitive restraint remained unchanged by tirzepatide treatment, participants reported reductions in disinhibition and perceived hunger