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Phase 2: Escalation (Weeks 5 to 8) Once you hit week five, the dose moves up to 0.5 mg weekly

Spreading that across three meals requires more total eating time than a 6-hour window comfortably accommodates when appetite is suppressed

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Physical discomfort is common from the weight of the tissue itself, chafing against clothing, or interference with exercise

head-to-head comparative data are not yet available, and speculative comparisons should be interpreted cautiously