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Association between glutathione-S-transferase GSTP1 genotypes, GSTP1 over-expression, and outcome in epithelial ovarian cancer

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The engineering is three pieces: an Aib8 substitution that blocks DPP-IV cleavage at the vulnerable N-terminal site, an Arg34 substitution that reduces a second clearance pathway, and a C18 fatty diacid linker that binds serum albumin and tethers the peptide to a carrier protein large enough to slow renal filtration

These are indirect effects, secondary consequences of the gastrointestinal side effects that tirzepatide is known for

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