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The final pillar of pathophysiology in these complex chronic conditions is oxidative stress

A pooled analysis of the STEP 1-3 trials (n=2,117 semaglutide 2.4 mg, n=1,262 placebo) reported GI adverse events in 72.9% of the semaglutide group versus 47.1% of placebo, with nausea (43.9% vs 16.1%), diarrhea (29.7% vs 15.9%), vomiting (24.5% vs 6.3%), and constipation (24.2% vs 11.1%) the most common categories

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Indeed, preventing micelle formation via common bile duct ligation abolishes GIP secretion upon a lard gavage compared to sham controls, independent of meal transit (Shibue et al., 2015)

Aim for a high-protein intake, around 1.6 to 2.2 grams per kilogram of your target body weight per day

The morning after, prioritize electrolyte-rich fluids before coffee or food