Treatment with liraglutide was shown to modulate the diversity of the gut microbiota in experiments conducted on animals on a high-fat diet [113, 114]
Ideal candidates typically include those who have struggled with traditional dieting, have insulin resistance or prediabetes, or need to lose 15 or more pounds
While gastrointestinal side effects such as nausea were common, they were mild and temporary
Carnitine plays an essential role in the way that mitochondria use fats for fuel, and the study showed that mice deficient in a carnitine transporter, SLC25A45, didnt lose weight as easily on a GLP-1 RA medication.[ref] Related article: Carnitine genes GLP-1 Beyond Weight Loss: Heart Disease, Alzheimers, Cancer, and Immunity Recent studies show that the benefits of GLP-1 RA medications extend beyond weight loss
But research over the past several years has made one thing clear: The brain plays a central role in how these drugs suppress appetite
The drugs are approved in Canada for diabetic treatment