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Fuentes, Nathalie, and Patricia Silveyra

Although with some controversy, the accumulated evidence directly supports an age-related decline in the ability to respond to OS with the activation of the NRF2/ARE signalling pathway, thereby reducing the expression of its target antioxidant genes [327]

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J Gerontol A Biol Sci Med Sci 61 (8), 806812

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This is one of the reasons published Tirzepatide research is typically discussed not only in terms of efficacy, but also in terms of tolerability during escalation , GI event burden and the balance between metabolic benefit and dropout risk