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We reviewed human data to obtain the following preliminary conclusions concerning insulin/IGF-1 modulation in humans: (i) DR could be considered as a supportive treatment during cancer therapy due to its probable antitumor effects, and due to its beneficial effects on human metabolism

10.1007/s11033-022-07468-0 12 GrubeM.AmelingS.NoutsiasM.KckK.TriebelI.BonitzK.et al (2011)

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Upon dermal contact, these particles are detected by pattern recognition receptors (PRRs) on a range of skin-resident cells, including keratinocytes, fibroblasts, dendritic cells, melanocytes, macrophages, and T lymphocytes