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Aberrant activation of Drp1 disrupts mitochondrial homeostasis, thereby triggering NLRP3 inflammasome activation and caspase-3 cleavage, which in turn amplify neuroinflammatory cascades (Elsherbini et al., 2020

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What was once viewed largely through a behavioral or moral lens is now firmly established as a chronic, relapsing brain disease rooted in neurobiological, psychological, and determinants