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We hypothesised that varying the timing of metformin administration before a standardised nutrient load would affect glucose-lowering, and, in this proof-of-concept study, we evaluate the effects of metformin administered by intraduodenal perfusion at different time intervals (0, 30 or 60 min) before a standardised intraduodenal glucose load on plasma glucose, GLP-1 and insulin levels in metformin-treated participants with type 2 diabetes

Due to the storage of cholecalciferols and calcidiol in adipose tissue, vitamin D intoxication can take several weeks to resolve