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However, the majority of the studies that have identified either rapid or normal GET were performed during the interspersed period, while those performed during the emetic phase have shown a significant gastric emptying delay, which might be related to either the activation of HPA axis resulting in the release of CRF, which inhibits foregut motility, or activation of dorsal vagal complex (DVC), which inhibits gastric motility via the efferent vagal pathway

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90.Wu, Q., Tian, A.-L., Durand, S., Aprahamian, F., Nirmalathasan, N., et al

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The company intends to resubmit the NDA during the first half of this year after a successful reinspection of the manufacturing site

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