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Gojkovicc et al., 2021a

BPC-157 is not FDA approved as a standard medication, and the FDA has identified concerns around compounded BPC-157, including possible immunogenicity risk, peptide-related impurities, and limited safety information for certain routes of administration

This sparked concerns that creatine could accelerate hair loss in genetically predisposed individuals

Several GLS inhibitors have been developed, among which CB-839 is currently undergoing clinical trials as a potent, orally bioavailable GLS-selective inhibitor for the treatment of various cancers, including TNBC, NSCLC, and colon cancer (NCT03057600, NCT03057600, NCT03057600, NCT03057600, NCT03057600, NCT03057600)

There are three genetically different isoforms of NOS

Axonal dystrophy was found in the nucleus gracilis, primarily in the exposed groups