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Hepatocytes were transfected with 2.75 M dsiRNA (Integrated DNA Technologies, Coralville, IA) in nuclease-free duplex buffer using the Viromer Blue transfection kit (Origene) following the manufacturers protocol

The OH depolymerizes GI mucin, inactivates pyruvate dehydrogenase, an essential mitochondrial enzyme, and damages mitochondrial RNA and DNA in the GI tract (113)

MTHFR gene SNPs influence how well you methylate, which is one of the cellular processes your body uses to operate both physically and mentally

doi: 10.1038/nrendo.2012.140 60 KhatDZHusainM

When mitochondrial depolarization damage occurs, the mitochondrial membrane potential (MMP) decreases, and PINK1 hydrolysis is inhibited, which stably binds to the damaged mitochondrial outer membrane, recruiting Parkin to translocate from the cytoplasm to the mitochondrial outer membrane, thereby phosphorylating and activating Parkin activity (Uoselis et al., 2023)

Evidence for CAT gene being functionally involved in the susceptibility of COVID-19