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E.3.2 Heme Binders Rational inspection The top 50 computationally ranked designs were visually inspected to ensure the heme was buried within the protein core, while the ligand placeholder remained exposed to the solvent to allow substrate access to the catalytic site

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Some patients have also experienced a hypersensitivity reaction following intramuscular injection that has resulted in anaphylactic shock and death

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Common Side Effects When side effects occurred, they were typically mild, transient, and similar in frequency to placebo groups: Reported Adverse Effects Most Common (occurring in small percentage of participants): Mild to moderate headaches (most frequently reported, often resolving with continued use) Injection site reactions (minor redness, swelling, or irritation at injection site) Gastrointestinal effects (particularly at higher oral doses: mild nausea, diarrhea, flatulence) Fatigue (reported occasionally during initial adaptation period) Rare Events: One case of chest tightness was deemed possibly related to treatment in safety trials