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This phenomenon is manifested by cellular swelling, plasma membrane rupture, and eventually the disappearance of cellular boundaries

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FIGURE 12 Collectively, these findings indicate that GO@GSH-FA effectively preserves neuronal integrity and reduces apoptosis in a cerebral Ischemia-Reperfusion injury model, demonstrating its potential as a therapeutic agent for neuroprotection

Magn Reson Med 69(4):937943 Scafidi J, Hammond TR, Scafidi S, Ritter J, Jablonska B, Roncal M, Szigeti-Buck K, Coman D, Huang Y, McCarter RJ Jr, Hyder F, Horvath TL, Gallo V (2014) Intranasal epidermal growth factor treatment rescues neonatal brain injury