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Once it absorbs a free-radical it needs to be converted back to the active form

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Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, et al

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The positive effect of minoxidil on hair growth is mainly due to its metabolite, minoxidil sulfate, and the enzyme responsible for this conversion is sulfotransferase, which is located in hair follicles and varies in production among individuals