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GLP1 receptors sit in brainstem regions that regulate nausea and visceral sensation

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The mechanism of action involves several physiological processes: Enhanced insulin secretion : They stimulate glucose-dependent insulin release from pancreatic beta cells, which helps lower blood glucose levels without causing hypoglycaemia when glucose levels are normal Suppressed glucagon secretion : They reduce inappropriate glucagon release from pancreatic alpha cells, further improving glycaemic control Delayed gastric emptying : They slow the rate at which food leaves the stomach, promoting satiety and reducing postprandial glucose excursions