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An alternative to enzymatic modification is to use site-specific incorporation of non-natural amino acid (nnAAs) with chemical side chains that are compatible with bio-orthogonal conjugation chemistry

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The inclusion criteria for the patients group consisted of mild to severe DE in in-patients aged 60 years with recurrent depressive disorder (RDD, F33.0-F33.3), bipolar disorder (BD, F31.3, F31.4), or single DE (F32.0-F32.2) by ICD-10

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