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The study quantified cytokines, neurotransmitters, oxidative stress markers and detoxification enzymes using ELISA-based assays, revealing that VPA exposure disrupted glutathione balance, increased IL-6, CYP450 and glutamate, and reduced serotonin and IFN-, while curcumin partially restored these alterations ( Furthermore, Yang and Bhandari employed a PPA-induced rat model of autism, using male-only Sprague-Dawley rats that received intracerebroventricular infusions of 1M PPA

The investigation was also supported by grants UL1RR025764 (University of Utah, Center for Clinical and Translational Sciences), UL1RR025005 (Johns Hopkins University, General Clinical Research Center), UL1RR025011 (University of Wisconsin, Clinical and Translational Research Core) M01-RR00034 (Ohio State University, General Clinical Research Center) and the Clinical Research Center, Children's Hospital of Michigan, given by the National Center for Research Resources, National Institutes of Health

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