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Multiple studies have demonstrated that both pharmacological inhibition and genetic ablation of complex I can influence ferroptosis sensitivity in various disease contexts, including cancer, skin photoaging, Parkinsons disease and intracerebral hemorrhage 103,104,105,106

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The binding site in S for COPI is sub-optimal The COPI binding region comprises KLHYT which differs somewhat from the canonical KXKXX or KKXX C-terminal COPI binding motif 35,39 , and it has been speculated for SARS-CoV that this non-canonical motif might allow more S to reach the surface, although this was not tested experimentally 20

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