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Furthermore, fatty acid analysis of human plasma showed that both linoleic acid (omega-6 series) and alpha-linolenic acid (omega-3 series) metabolites were significantly lower in the plasma phospholipid fraction of patients with SLE than in controls, suggesting altered essential fatty acid metabolism in these patients

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Folic acid, as a crucial methyl donor in one-carbon metabolism, directly contributes to the availability of S-adenosylmethionine (SAM), the universal methyl group donor for DNA methylation reactions [79, 80]

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