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S., Olsen, H

Eight weeks of aerobic exercise significantly activated the System Xc /GPx4 signaling pathway in the prefrontal cortex of APPswe/PS1dE9 transgenic AD mice, up-regulated FTL and BACE1 expression, significantly downregulated 4-HNE levels, inhibited oxidative stress, lipid peroxidation, and ferroptosis, reduced A positivity, alleviated neuronal morphological abnormalities, and improved learning and memory functions in AD mice (Li et al., 2024a)

10.1016/j.biopha.2021.111585 109 WuY.PiD.ChenY.ZuoQ.ZhouS.OuyangM.et al (2022)

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Researchers have not identified a lethal dose even at concentrations far exceeding therapeutic ranges