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[DOI] [PMC free article] [PubMed] [Google Scholar] 162.Pike S., Patel A., Stacey G., Gassmann W

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This perspective explains why early ERmitochondria Ca 2+ maladaptation, later lysosomal-autophagic failure, redox amplification, inflammasome activation, and cell-fate decisions are mechanistically linked, and it generates testable predictions about temporal ordering, reversibility, and disease-stage specificity of contact-site remodeling

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