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While short-term preclinical studies suggest favorable safety, chronic administration effects on angiogenesis, growth factor signaling, and tissue remodeling over years of use remain unknown

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B12 deficiency can result from dietary factors such as a lack of animal products or from conditions affecting absorption like pernicious anaemia or gastrointestinal surgery

Changes in intrarenal oxygenation as evaluated by BOLD MRI in a rat kidney model for radiocontrast nephropathy

10.1016/S0002-9440(10)63847-3