Clinical trials have shown tirzepatide produces greater average weight loss than semaglutide at equivalent timepoints, though individual response varies based on genetic and metabolic factors
Drawbacks: High cost, potential side effects (nausea, constipation, diarrhea often manageable), limited long-term data, and the need for lifestyle changes
Individual timelines vary based on genetics, diet, and dose escalation pace
Full normalization of endocrine, hepatic, and lipid profiles can take several months post-cycle, even with proper PCT. Kanayama, Current Opinion in Endocrinology, Diabetes and Obesity 2
The other was my inability to provide any degree of evidence outside of the safe and effective talking point to a friend who chose not to vaccinate her children and defended her stance with actual science
It is usually mild to moderate and improves with continued use