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125 GCGR knockout mice produced in one study had islet alpha-cell hyperplasia and these mice were additionally shown to have large increases of glucagon and GLP-1 levels in circulation, but interestingly they had lower plasma glucose levels throughout the day, similar insulin levels and improved glucose tolerance compared to GCGR+ control animals

Lactylation of Ca 2+ -signaling proteins contributes to calcium overload, mitochondrial dysfunction, and neuronal apoptosis (Yao Y

Neuroprotection from injury cascades After a neurological injury such as stroke, TBI, or the chronic damage seen in neurodegeneration a cascade of secondary injury events unfolds: excitotoxicity, uncontrolled apoptosis, oxidative stress, and neuroinflammation

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