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10.1161/CIRCHEARTFAILURE.108.766402

Dutta, P., Kumar, Y., Babu, A

Why DDIs Matter in Drug Discovery & Development Influence dose selection and labeling Drive clinical trial design Affect real-world safety Require early evaluation during ADME-Tox studies Understanding DDIs early prevents late-stage surprises

The most common codes are PA-NOT-MET, NF (non-formulary), STEP-REQ (step therapy required), BMI-NOT-MET, and EMP-EXCL (employer carve-out)