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The compound's procognitive effects stem from its ability to enhance synaptogenesisthe formation of new functional synapses between neuronsparticularly in the hippocampus, a brain region essential for learning and memory consolidation

In trials, acute pancreatitis occurred in 4 Wegovy-treated patients (0.2 cases per 100 patient-years) and 1 placebo-treated patient ( 60 years)

The efficacy analysis included 54 adult patients with advanced or metastatic NTRK fusionpositive solid tumors.[41] The objective response rate was 57% (95% CI, 34.2%70.8%)

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Peer review Peer review information Nature Reviews Rheumatology thanks Maria Sole Chimenti, Rubn Queiro and Eric Toussirot for their contribution to the peer review of this work