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However, the inherent biosafety, large-scale production processes, and cost-effectiveness of these complex systems are practical issues that must be resolved before they can enter clinical practice

Regulation of NAD + availability by PARP inhibitors and NAD + precursor modulates mitochondrial function through sir-2.1 in worm to extend lifespan

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Available at: Iborra A, Palacio JR, Martinez P

Acta Obstet Gynecol Scand

doi:10.1146/annurev.pharmtox.45.120403.095857 [PubMed] 15