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In a study that compared the effects of duloxetine and placebo in 457 patients with a score of 3 on the MNSI, duloxetine at a dose of 60 or 120 mg/day improved pain from the first week of administration and was continuously effective throughout the study compared with placebo

Pacific Medical Surgeon Journal , 1866;9:239-240

Collectively, this data strongly suggests that prolonged THC exposure can induce significant oxidative stress in neuronal populations and may thus dysregulate neurodevelopmental processes required for healthy cognitive and affective function

In the ACL, oxidative stress can impair fibroblast function and promote ECM degradation

doi:10.3389/fnagi.2022.1077384 54

EPA and DHA alleviated chronic dextran sulfate sodium exposure-induced depressive-like behaviors in mice and potential mechanisms involved