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Asian Pacific journal of tropical biomedicine, 3 (4), 253266.
Further electrophysiological study showed that, opposite to the effects on arcuate POMC neurons, GLP-1 hyperpolarizes arcuate NPY neurons indirectly via increased GABA A receptor-mediated neurotransmission of local GABAergic interneurons (Secher et al., 2014
The results revealed that Neuroactive ligand-receptor interaction and Calcium signaling pathway were the primary mechanisms through which this combination exerted synergistic effects
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