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3.5 Lixisenatide is less effective in vivo GLP-1RAs are primarily used for the treatment of T2D to reduce glycaemia and promote weight loss through appetite reduction

Then this whole thing came out about this TMAO hypothesis, which I think is a hypothesis

"Serum N(1)-Methylnicotinamide Is Associated With Obesity and Diabetes in Chinese." Journal of Clinical Endocrinology & Metabolism

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1D) showed that PLB significantly down-regulated cytochrome C and Ferritin, while up-regulating TFAM and GPX4, suggesting that PLB promotes the survival and functional recovery of ovarian cells by regulating apoptosis and ferroptosis-related pathways