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Following secretion, PYY is rapidly cleaved by dipeptidyl peptidase-4 (DPP-4) to its active form (PYY 3-36) acting on neuropeptide Y receptor type 2 (Y2R)

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62 A case series linked the use of semaglutide or tirzepatide with an increased risk of NAION, sometimes after a single dose, including in one patient without diabetes and in another who experienced symptoms in both eyes following separate doses

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