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doi: 10.1016/j.bbagen.2016.10.008

Four RCTs [17, 18, 32, 35] involving 291 patients provided moderate certainty evidence (Table 2) that L-carnitine supplementation has no difference in changes in weight (MD: 0.20, 95%CI: 0.50 to 0.09)

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Moreover, Litwinienko and Ingold proposed a modified SPLET mechanism in 2004, particularly relevant in solvents that facilitate ionization, such as methanol among organic solvents (Litwinienko and Ingold 2003)

Dopaminergic system modulation has been investigated as a therapeutic approach for tinnitus 130 based on evidence that the salience and emotional impact of tinnitus may be mediated by dopaminergic pathways in the mesolimbic and prefrontal regions

Although there is no proven causal link in humans, the precautionary principle suggests careful consideration in patients with previous MTC