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The Role of NRF2 in Mitigating Oxidative-Stress-Induced HSC Activation NRF2 activation plays a crucial role in ameliorating liver fibrosis by interfering with the activation of HSCs, which are the key drivers of excessive ECM production

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Epigenetic changes amplifying Nrf2 amount or DNA methylation reducing Keap1 levels have been also described as further mechanisms to promote persistent activation of Nrf2 signalling [75]

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