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This induces a conformational change in the sensor protein, allowing it to recruit the adaptor protein and initiate the assembly of the inflammasome complex

doi: 10.1038/s41581-022-00647-z 84 KuskunovT.TilkiyanE.DoykovD.BoyanovK.BivolarskaA.HristovB

PMID: 21977314

Rapid dose escalation significantly increases the severity and duration of gastrointestinal side effects

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Contexto de via/mecanismo A ipamorelina usada para investigar a sinalizao de GPCRs ligada ao GHSR-1a, na qual o engajamento do receptor pode desencadear a mobilizao de clcio e a modulao da atividade da adenilato ciclase, levando a eventos de fosforilao subsequentes e respostas transcricionais