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The body can finally downregulate its stress response and enter parasympathetic (rest-and-digest) mode instead of remaining in sympathetic (fight-or-flight) activation

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Also investigated (29) was the effect of this intervention on neurophysiologic function that was assessed on the basis of peripheral nerve conductivity

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The COR-I trial, involving 1,742 participants over 56 weeks, demonstrated 6.1% average weight loss with Contrave versus 1.3% with placebo (Greenway et al., Obesity, 2010)