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Furthermore, non-canonical routes to acetyl-CoA production outside of mitochondria have also been proposed, with several studies reporting a moonlighting function of the pyruvate dehydrogenase complex (PDC), which can translocate to the nucleus under specific conditions to generate a local source of acetyl-CoA from pyruvate for histone acetylation 1518

doi: 10.2147/IJN.S162087

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