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A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007

Single molecule imaging by uPAINT The single molecule uPAINT experiments to detect and track endogenous and over-expressed Syt1 on the plasma membrane were performed as described previously 34,79

Weekly internal quality control testing monitors batch-to-batch consistency, traceability, and product integrity

(PubMed) Shen L, Ji HF