Eur J Immunol 32:286673, PMID: 12355439 Palomares T, Alonso-Varona A, Alvarez A, Castro B, Calle Y, Bilbao P (1997) Interleukin-2 increases intracellular glutathione levels and reverses the growth inhibiting effects of cyclophosphamide on B16 melanoma cells
C., Baynes, J
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developed a novel DON prodrug, HDON, which can selectively activate nitroreductase in hypoxic tumor environments without affecting oxygen-rich normal tissues, showing significant tumor inhibition in the H22 mouse liver cancer model (Zheng et al., 2024)
At clinical doses, the peptide activates collagen synthesis, accelerates cell turnover, and modulates the inflammatory response across multiple tissue types