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doi: 10.6026/97320630013356 PMCID: PMC5712779 Molecular docking analysis of curcumin analogues with COX-2 Mario Rowan Sohilait, Harno Dwi Pranowo, and Winarto Haryadi Pain Med

In addition to the reported events, the FDA is concerned the real number of consumers experiencing adverse events is higher due to underreporting

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The compounds quinolinium scaffold mimics nicotinamides structure, allowing it to compete for the NNMT active site while avoiding interactions with other enzymes

In the case of severe vitamin B12 deficiency, consider discussing with your physician whether vitamin B12 injections can be an appropriate option

Adequate protein intake, biotin supplementation, and avoiding excessively rapid weight loss (more than 2-3 pounds per week) reduce the risk