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In patients who already had substance use disorders, starting the GLP-1s was linked with a 31 per cent lower risk of emergency department visits, 26 per cent lower risk of hospitalizations, 25 per cent lower risk of suicidal thoughts or attempts, 39 per cent lower risk of overdose and 50 per cent lower risk of death

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However, there is evidence from case series and expert consensus that a number of non-opioid-based treatment that can be effective