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A small cup-to-disc ratio (the size relationship between two structures at the back of the eye where the optic nerve enters) is considered the strongest anatomical risk factor for NAION High blood pressure, diabetes, sleep apnea, and smoking each raise the risk independently Having had NAION in one eye increases the risk of developing it in the other Your eye care provider can measure your cup-to-disc ratio during a standard dilated eye exam

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DPP-4 inhibitors in clinical use today exhibit little or no binding to either DPP-8 or DPP-9

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