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These phosphorylated tyrosines serve as docking sites for adaptor proteins including insulin receptor substrate-1 (IRS-1), insulin receptor substrate-2 (IRS-2), and Shc, which are recruited to the activated receptor and themselves become phosphorylated, initiating multiple downstream signaling cascades

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doi: 10.1159/000497385

Subcutaneous Injection Technique Use insulin syringes with 29 to 31 gauge needles for comfortable subcutaneous injections

Implications for Cognitive Health during Aging and the Treatment of Alzheimer's Disease